FIGURE 6.
Inhibition of Src kinase and STAT3 of CD24-mediated cell invasion. A–C, percentage of invasive cells (mean ± S.D.) of CD24neg (A), CD24low (B), and CD24high cells (C) determined after 3 days in the presence of an Src inhibitory peptide (Src inh 30 μm), STAT3 inhibitor (STAT3 inh 30 μm), the tyrosine kinase inhibitor herbimycin A (HerbA, 100 μm), or DMSO as control. Invasion profiles of CD24neg, CD24low, and CD24high cells treated with DMSO control (D), Src inhibitory (E), (*, p < 0.05; (F), or herbimycin A (G). (*, p < 0.05; **, p < 0.05; ***, p < 0.001).