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Prediction of transmembrane domain and orientation of MB-COMT protein using PRED-TMR2. A, complete amino acid sequence of MB-COMT with the transmembrane domain and the catalytic domain indicated with bold letters. B, orientation of MB-COMT predicted by PRE-TMR2 showing that only six amino acids at the N terminus are intracellular and most amino acid sequences, including the catalytic domain, are extracellular.
