FIGURE 6.

Effect of tolcapone on human lymphoblastoid cells with COMT Val/Val and Met/Met genotypes. Human lymphoblastoid cells were treated with different doses of tolcapone for 24 h in 2% FBS medium. A, the survival of human lymphoblastoid cells with the Val/Val and Met/Met genotypes were measured and presented as percentages of controls treated with vehicle dimethyl sulfoxide (DMSO) in the bar graph. B, COMT enzyme activity in human lymphoblastoid cells with the Val/Val and Met/Met genotypes. C, relative COMT protein levels of human lymphoblastoid cells with Val/Val and Met/Met genotypes from Western blotting analyses.