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Calpain activity is significantly decreased in the presence of CAST. A, calpain activity was significantly increased in cells treated with paclitaxel. Cells transfected with CAST 24 h prior to 6-h paclitaxel treatment had significantly reduced calpain activity. B, Western blot analysis shows that m-calpain, and not μ-calpain, levels were affected by 6-h paclitaxel treatment. Error bars, S.E.
