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. 2011 Oct;12(3):253–264. doi: 10.1089/ham.2010.1076

FIG. 2.

FIG. 2.

Extracellular Ca2+ is vital for 5-HT-elicited pulmonary arterial contractility. Isometric tension recording of pulmonary arterial rings constricted in the presence (gray tracing) or absence (black tracing) of 2 mM extracellular Ca2+ from (A) normoxic and (B) LTH sheep. Tracings are plotted in relation to maximal contraction from an initial 10 μM 5-HT stimulation (% T5-HT Control). (C) Bars indicate mean±S.E.M. of 5-HT-induced contraction expressed as % T5-HT Control in the presence or absence of extracellular Ca2+ for pulmonary arteries from normoxic (open) and LTH (solid) adult sheep. ***p<0.001) denotes significant difference by 2-way ANOVA.