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. 2011 Oct;12(3):253–264. doi: 10.1089/ham.2010.1076

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Copyright 2011, Mary Ann Liebert, Inc.

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FIG. 4. — The role for L-type Ca²⁺ channels during 5-HT-mediated pulmonary arterial contractility may be affected by LTH in sheep. Bars indicate mean±S.E.M. based on isometric tension recordings of pulmonary arterial rings constricted with 10 μM 5-HT in the presence of 0.1% DMSO, 10 μM nifedipine (NIF), 10 μM nifedipine plus 50 μM SKF 96365, 10 μM diltiazem (Dilt), or 10 μM Verapamil (Ver) from normoxic (open) and LTH (solid) sheep. Values of the 5-HT induced contraction are expressed as % T5-HT Control in the presence or absence of the above antagonists. *p<0.05, ***p<0.001 denotes significant difference by 2-way ANOVA.