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. 2011 Oct;12(3):253–264. doi: 10.1089/ham.2010.1076

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Copyright 2011, Mary Ann Liebert, Inc.

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FIG. 5. — Gd³⁺, La³⁺, and low dose Ni²⁺ inhibit 5-HT-elicited pulmonary arterial ring contractility in sheep. Bars indicate mean±S.E.M. based on isometric tension recordings of pulmonary arterial rings from adult sheep constricted with 10 μM 5-HT in the absence or presence of 500 μM Ni²⁺, 100 μM Gd³⁺, or 100 μM La³⁺ in normoxic (open) or LTH (solid) sheep. Values of the 5-HT-induced contraction are expressed as % T5-HT Control for the noted condition. ***p<0.001 denotes significant difference by 2-way ANOVA.