Table S3.
Preferred terms in the broad major adverse cardiovascular events (MACE) category
| Central nervous system hemorrhages and cerebrovascular conditions* | ||
|---|---|---|
| Agnosia | Hematomyelia | Cerebellar ischemia |
| Amaurosis fugax | Hemorrhage intracranial | Cerebral arteriosclerosis |
| Angiogram cerebral abnormal | Hemorrhagic cerebral infarction | Cerebral artery embolism |
| Aphasia | Hemorrhagic stroke | Cerebral artery occlusion |
| Balint’s syndrome | Hemorrhagic transformation stroke | Cerebral artery stenosis |
| Carotid artery aneurysm | Intracerebral hematoma evacuation | Cerebral artery thrombosis |
| Carotid artery dissection | Intracranial hematoma | Cerebral infarction |
| Central pain syndrome | Intraventricular hemorrhage | Cerebral infarction fetal |
| Cerebral aneurysm ruptured syphilitic | Intraventricular hemorrhage neonatal | Cerebral ischemia |
| Cerebrovascular accident prophylaxis | Meningorrhagia | Cerebral revascularization synangiosis |
| Charcot–Bouchard microaneurysms | Putamen hemorrhage | Cerebral thrombosis |
| Diplegia | Ruptured cerebral aneurysm | Cerebral vasoconstriction |
| Dysarthria | Spinal cord hemorrhage | Cerebral venous thrombosis |
| Hemiparesis | Spinal epidural hemorrhage | Cerebrovascular accident |
| Hemiplegia | Spinal hematoma | Cerebrovascular disorder |
| Intra-cerebral aneurysm operation | Stroke in evolution | Cerebrovascular insufficiency |
| Intracranial aneurysm | Subarachnoid hemorrhage | Cerebrovascular spasm |
| Monoparesis | Subarachnoid hemorrhage neonatal | Cerebrovascular stenosis |
| Monoplegia | Subdural hemorrhage | Embolic cerebral infarction |
| Paralysis | Subdural hemorrhage neonatal | Embolic stroke |
| Paralysis flaccid | Thalamus hemorrhage | Ischemic cerebral infarction |
| Paraparesis | Basal ganglia infarction | Ischemic stroke |
| Paraplegia | Basilar artery occlusion | Lacunar infarction |
| Paresis | Basilar artery stenosis | Lateral medullary syndrome |
| Quadriparesis | Basilar artery thrombosis | Millard–Gubler syndrome |
| Quadriplegia | Brain stem infarction | Moyamoya disease |
| Red blood cells CSF positive | Brain stem ischemia | Post procedural stroke |
| Spastic paralysis | Brain stem stroke | Precerebral artery occlusion |
| Spastic paraplegia | Brain stem thrombosis | Reversible ischemic neurological deficit |
| Visual midline shift syndrome | Capsular warning syndrome | Spinal artery embolism |
| Basal ganglia hemorrhage | Carotid arterial embolus | Stroke in evolution |
| Brain stem hemorrhage | Carotid arteriosclerosis | Thalamic infarction |
| Brain stem stroke | Carotid artery bypass | Thrombotic cerebral infarction |
| Carotid aneurysm rupture | Carotid artery disease | Thrombotic stroke |
| Cerebellar hematoma | Carotid artery insufficiency | Transient ischemic attack |
| Cerebellar hemorrhage | Carotid artery occlusion | Vascular encephalopathy |
| Cerebral arteriovenous malformation hemorrhagic | Carotid artery stenosis | Vertebral artery occlusion |
| Cerebral hematoma | Carotid artery stent insertion | Vertebral artery stenosis |
| Cerebral hemorrhage | Carotid artery thrombosis | Vertebral artery thrombosis |
| Cerebral hemorrhage fetal | Carotid endarterectomy | Vertebrobasilar insufficiency |
| Cerebral hemorrhage neonatal | Cerebellar artery occlusion | Wallenberg syndrome |
| Cerebral microhemorrhage | Cerebellar artery thrombosis | Brachiocephalic artery occlusion |
| Cerebrovascular accident | Cerebellar embolism | Carotid artery stent removal |
| Cerebrovascular disorder | Cerebellar infarction | |
|
Myocardial infarction* | ||
| Acute coronary syndrome | Coronary artery thrombosis | Papillary muscle infarction |
| Acute myocardial infarction | Coronary bypass thrombosis | Post procedural myocardial infarction |
| Blood creatine phosphokinase abnormal | Electrocardiogram Q wave abnormal | Postinfarction angina |
| Blood creatine phosphokinase increased | Electrocardiogram ST segment abnormal | Scan myocardial perfusion abnormal |
| Blood creatine phosphokinase MB abnormal | Electrocardiogram ST segment elevation | Silent myocardial infarction |
| Blood creatine phosphokinase MB increased | Electrocardiogram ST-T segment elevation | Troponin I increased |
| Cardiac enzymes increased | Infarction | Troponin increased |
| Coronary artery embolism | Kounis syndrome | Troponin T increased |
| Coronary artery occlusion | Myocardial infarction | Vascular graft occlusion |
| Coronary artery reocclusion | Myocardial reperfusion injury | |
*
Notes: Level 2 standardized Medical Dictionary of Regulatory Activities (MedDRA) query (SMQs) (subgroups of the “ischemic heart disease” and “cerebrovascular disorders” Level 1 SMQs, respectively) from MedDRA version 13.0.