Table 5.
Major adverse cardiovascular events (MACE) episodes
| IND 75 n = 449 |
IND 150 n = 2611 |
IND 300 n = 1157 |
IND 600 n = 547 |
FOR n = 556 |
SLM n = 895 |
TIO n = 1214 |
PBO n = 2012 |
|
|---|---|---|---|---|---|---|---|---|
| Total patient years | 105.06 | 859.72 | 736.97 | 394.49 | 396.21 | 274.93 | 357.97 | 923.60 |
| Broad MACE | ||||||||
| Patients with ≥1 event, n (%) | 4 (0.89) | 21 (0.80) | 8 (0.69) | 6 (1.10) | 7 (1.26) | 7 (0.78) | 11 (0.91) | 29 (1.44) |
| Events per patient-year (n) | 0.04 | 0.04 | 0.01 | 0.02 | 0.02 | 0.03 | 0.04 | 0.04 |
| Custom MACE | ||||||||
| Patients with ≥1 event, n (%) | 1 (0.22) | 14 (0.54) | 5 (0.43) | 3 (0.55) | 4 (0.72) | 4 (0.45) | 4 (0.33) | 19 (0.94) |
| Events per patient-year (n) | 0.01 | 0.02 | 0.01 | 0.01 | 0.01 | 0.02 | 0.01 | 0.02 |
Abbreviations: IND, indacaterol; FOR, formoterol; SLM, salmeterol; TIO, tiotropium; PBO, placebo; n, number.