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. 2011 Oct 4;6(10):e26000. doi: 10.1371/journal.pone.0026000

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Li et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) A coronal section with Nissl staining of E15.5 wild type mouse brains. The highlighted region is the developing hippocampus. The hippocampal neuroepithelium (HN, arrow) and dentate gyrus (DG) are labeled. (B, C) Numbers of progenitors in the HN and DG regions were greatly reduced when Dicer was ablated in early developing brains. Progenitors were detected with anti-Ki67, anti-BrdU, and anti-PH3 antibodies in E15.5 Emx1-Dicer cko, Nestin-Dicer cko and control (Ctrl) brains. (D, E) Quantification of Ki67⁺, BrdU⁺ and PH3⁺ cells in the E15.5 HN and DG regions. At least three Emx1-Dicer cko, Nestin-Dicer cko and three control animals were used for all statistical analysis. n>3, *, P<0.05; **, P<0.01; ***, P<0.001.