Skip to main content
. Author manuscript; available in PMC: 2012 Oct 15.
Published in final edited form as: Biol Psychiatry. 2011 Jul 23;70(8):712–719. doi: 10.1016/j.biopsych.2011.06.010

Figure 2.

Figure 2

Moxonidine, an imidazoline-1 (I1) receptor-preferring agonist, reduced cue-induced reinstatement of extinguished cocaine-seeking, as well as cocaine-induced reinstatement and extinction responding. (A) Moxonidine significantly attenuated cue-induced reinstatement at 1 mg/kg, but not 0.2 mg/kg (n=10), as compared to vehicle (**p<0.01). Extinction (ext) levels of responding prior to reinstatement are also shown. (B) Pretreatment with the selective α2 antagonist RS-79948 (1 mg/kg) blocked the effects of 1 mg/kg moxonidine on cue-induced reinstatement (n=12; *p<0.05, as compared to 0/0 vehicle condition), indicating that the effects of moxonidine required actions at α2 receptors. (C) Moxonidine significantly attenuated reinstatement elicited by a cocaine prime (n=12), as compared to vehicle (*p<0.05). (D) Chronic moxonidine reduced cocaine-seeking on the first days of extinction following 3 weeks of abstinence from self-administration (n=8 and 8). There was a rebound of responding when moxonidine pretreatment was discontinued after 7 days (*p<0.05, ***p<0.001).