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. Author manuscript; available in PMC: 2012 Oct 15.
Published in final edited form as: Biol Psychiatry. 2011 Jul 23;70(8):712–719. doi: 10.1016/j.biopsych.2011.06.010

Figure 3.

Figure 3

Prazosin plus propranolol reduced cue-induced reinstatement of extinguished cocaine-seeking. (A) The α1 antagonist prazosin had no significant effect on cue-induced reinstatement at 1 or 3 mg/kg (n=15). Extinction (ext) levels of responding prior to reinstatement are also shown. (B)The β antagonist propranolol had no effect on cue-induced reinstatement at 5 mg/kg (n= 11) or 10 mg/kg (n=9). (C) Combined pretreatment with prazosin (1 mg/kg) plus propranolol (10 mg/kg) significantly attenuated cue-induced reinstatement (n=9), as compared to vehicle (*p<0.05).