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Corticotropin-releasing factor receptor-1 (CRF R1) antagonists reduced cue-induced reinstatement of extinguished cocaine-seeking. (A)CP-154,526 significantly attenuated cue-induced reinstatement at 20 mg/kg (n=6), as compared to vehicle (*p<0.05). Extinction (ext) levels of responding prior to reinstatement are also shown. (B)Antalarmin showed a trend for reducing cue-induced reinstatement at 20 mg/kg (n=11), but not 10 mg/kg (n=12), as compared to vehicle.
