Figure 4. Performance of the miRNA-based predictor to distinguish the type of MSI.

A) Receiver operating curve of the miRNA-based predictor (miR-622, miR-362-5p, miR-486-5p) to distinguish the presence of Lynch syndrome among MSI tumors. S1, training set (n=14); S2, test set (n=33). B) Discriminant probability plot. The graphical representation shows the LOO-CV probabilities (0.0 to 1.0) of each tumor for being sporadic MSI (red dots and triangles) or Lynch syndrome (blue dots and triangles). Dots indicate samples from the training set (set 1) and triangles from the test set (set 2).