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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Microvasc Res. 2011 May 14;83(1):64–70. doi: 10.1016/j.mvr.2011.05.002

Fig. 1.

Fig. 1

Angiogenesis. Mesenchymal stem cells of mesodermal origin give rise to hemangioblasts are derived from mesoderm. Transcription factor Brachyury is required for mesoderm formation and differentiation. Hemangioblasts can give rise to hematopoietic cells and angioblasts. Whereas a subset of VE-cadherin+ and Runx-1+ endothelial cells, called “hemogenic endothelial cells” can also give rise to hematopoietic stem cells that have the ability to home into the liver. Angiogenesis requires activities of endothelial cells, as well as accessory cells including hematopoietic, pericytes and smooth muscle cells.