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. Author manuscript; available in PMC: 2012 Oct 15.
Published in final edited form as: Biol Psychiatry. 2011 Jul 14;70(8):744–753. doi: 10.1016/j.biopsych.2011.05.021

Figure 6.

Figure 6

Temporal effects of acute and repeated salvA on P-ERK and P-CREB in the NAc. Rats were treated with vehicle (H2O) or norBNI (20 mg/kg) 24 hr prior to administration of acute or repeated (d1–5 and 8) vehicle (75% DMSO) or salvA (2.0 mg/kg/d) and were sacrificed 15-min (acute) or 24-hr (repeated) after the last salvA treatment. Tissue punches from the NAc and CPu were extracted for measurement of ERK and CREB activation. (A) Acute salvA significantly increased the level of P-ERK, and this effect was blocked by norBNI pretreatment. (B) Acute salvA had no effect on P-CREB. (C) Prior, repeated salvA significantly increased P-ERK and P-CREB (D) in the NAc and this effect was blocked by norBNI pretreatment (d0). Representative Western blots are shown to the right of each graph. Data are expressed as mean (±SEM) fold induction of protein of interest relative to Veh + Veh control group. *p<0.05, compared to Veh + Veh group, #p<0.05 comparing groups under the bar. Bonferroni/Dunn’s correction N=5–9 rats/group.