Table 2.

Effects of adoptive transfer of ALDH1A1_88–96 peptide-specific CD8⁺ T cells on PCI-13-derived xenografts in immunodeficient mice^a.

Group	Δ MTV±SDb	% ALDHbright cellsc	Proliferation Indexd	Apoptotic Indexe
Control	676±45	1.3±0.8	172±18	22±7
Irrelevant CD8+ T cells	662±11	1.8±0.5	176±33	25±7
ALDH1A188–96 peptide-specific CD8+ T cells	398±33 p = 8×10−7	0.4±0.3 p = 0.009	90±25 p = 4×10−5	41±9 p = 0.01

^aSee Material and Methods sections for protocol used. Two-tailed student’s t test based on values of untreated control groups of mice was used to determine significance.

^bThe difference (Δ) in mean volume (mm³) of each tumor in a mice on days 7 and 20 was determined and the values expressed as mean tumor volume (MTV) ±SD for each group.

^cPercentages based on gated events.

^dMean ± SD of histoneH3 phosphoserine10⁺ cells per tumor as analyzed by IHC as detailed in Materials and Methods section.

^eMean ± SD of TUNEL⁺ cells per tumor as analyzed by IHC as detailed in Materials and Methods section.