Table 3.
Combined efficacy of CPV and other inhibitors of CMV replication
| Drug combination | Vol of synergy or antagonism (μM2log10 GE) |
|
|---|---|---|
| Avga | Value at 95% confidenceb | |
| CPV-PFA | 5 ± 0.57 | 0.8 ± 0.15 |
| CPV-GCV | −9.2 ± 0.99 | −5.3 ± 1.9 |
| MBV-GCV | −12 ± 0.57 | −7.3 ± 0.49 |
| MBV-CPV | −27 ± 3.8 | −19 ± 1.9 |
a
Shown are average volumes from two independent experiments, with values of >0 indicating synergy and values of <0 indicating antagonism.
b
Values shown at 95% confidence represent conservative estimates of synergy or antagonism obtained by using the lower bound of the 95% confidence interval to calculate the volumes rather than the average of the experimental data.