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. 2011 Oct;55(10):4643–4651. doi: 10.1128/AAC.00384-11

Table 1.

Antimicrobial sensitivities of G. lamblia lines used in the study

G. lamblia line EC50 (ratio)a
Metronidazole Tinidazole Ornidazole Nitazoxanide Furazolidone Quinacrine
WB 2.9 ± 0.2 (1.0) 0.5 ± 0.3 (1.0) 0.8 ± 0.3 (1.0) 2.8 ± 0.9 (1.0) 1.1 ± 0.4 (1.0) 0.17 ± 0.02 (1.0)
WB-M1 34.7 ± 4.6 (11.9) 3.5 ± 0.9 (6.5) 6.0 ± 1.2 (7.3) 22.0 ± 3.6 (7.9) 2.3 ± 0.9 (2.2) 0.16 ± 0.08 (0.9)
WB-M1NR 3.4 ± 0.5 (1.2) 0.6 ± 0.1 (1.1) 1.0 ± 0.1 (1.2) 1.6 ± 0.4 (0.6) 0.5 ± 0.1 (0.5) 0.14 ± 0.01 (0.8)
WB-M2 80.4 ± 7.5 (27.5) 19.6 ± 3.8 (36.3) 29.4 ± 7.3 (35.9) 37.1 ± 9.1 (13.5) 3.3 ± 0.5 (3.1) 0.16 ± 0.02 (0.9)
106 3.6 ± 0.6 (1.0) 1.1 ± 0.3 (1.0) 1.3 ± 0.2 (1.0) 5.1 ± 1.5 (1.0) 0.7 ± 0.1 (1.0) 0.28 ± 0.07 (1.0)
106-2ID10 78.4 ± 7.7 (21.6) 24.1 ± 3.4 (22.0) 40.6 ± 6.6 (30.3) 28.2 ± 6.7 (5.5) 3.5 ± 0.9 (4.9) 0.17 ± 0.00 (0.6)
106-C17A 61.0 ± 8.7 (16.8) 20.5 ± 3.2 (18.7) 24.5 ± 3.8 (18.3) 16.0 ± 3.4 (3.6) 6.0 ± 1.9 (8.6) 0.17 ± 0.03 (0.6)
713 2.0 ± 0.3 (1.0) 1.6 ± 0.3 (1.0) 1.8 ± 0.2 (1.0) 2.8 ± 0.4 (1.0) 0.4 ± 0.1 (1.0) 0.18 ± 0.01 (1.0)
713-M3 50.2 ± 3.6 (24.9) 7.1 ± 0.7 (4.6) 10.1 ± 1.7 (5.5) 21.8 ± 1.6 (7.9) 3.0 ± 0.7 (8.0) 0.18 ± 0.03 (1.0)
a

Activity of the indicated antimicrobials against G. lamblia was determined as the EC50, the compound concentration (in μM) that inhibited growth of the parasite by 50% over the assay period. Data are means ± SEM of the results of 3 to 4 separate experiments. Ratios are relative to the mean EC50 of the respective parental isolate for each antimicrobial drug.