Table 1.
Antimicrobial sensitivities of G. lamblia lines used in the study
| G. lamblia line | EC50 (ratio)a |
|||||
|---|---|---|---|---|---|---|
| Metronidazole | Tinidazole | Ornidazole | Nitazoxanide | Furazolidone | Quinacrine | |
| WB | 2.9 ± 0.2 (1.0) | 0.5 ± 0.3 (1.0) | 0.8 ± 0.3 (1.0) | 2.8 ± 0.9 (1.0) | 1.1 ± 0.4 (1.0) | 0.17 ± 0.02 (1.0) |
| WB-M1 | 34.7 ± 4.6 (11.9) | 3.5 ± 0.9 (6.5) | 6.0 ± 1.2 (7.3) | 22.0 ± 3.6 (7.9) | 2.3 ± 0.9 (2.2) | 0.16 ± 0.08 (0.9) |
| WB-M1NR | 3.4 ± 0.5 (1.2) | 0.6 ± 0.1 (1.1) | 1.0 ± 0.1 (1.2) | 1.6 ± 0.4 (0.6) | 0.5 ± 0.1 (0.5) | 0.14 ± 0.01 (0.8) |
| WB-M2 | 80.4 ± 7.5 (27.5) | 19.6 ± 3.8 (36.3) | 29.4 ± 7.3 (35.9) | 37.1 ± 9.1 (13.5) | 3.3 ± 0.5 (3.1) | 0.16 ± 0.02 (0.9) |
| 106 | 3.6 ± 0.6 (1.0) | 1.1 ± 0.3 (1.0) | 1.3 ± 0.2 (1.0) | 5.1 ± 1.5 (1.0) | 0.7 ± 0.1 (1.0) | 0.28 ± 0.07 (1.0) |
| 106-2ID10 | 78.4 ± 7.7 (21.6) | 24.1 ± 3.4 (22.0) | 40.6 ± 6.6 (30.3) | 28.2 ± 6.7 (5.5) | 3.5 ± 0.9 (4.9) | 0.17 ± 0.00 (0.6) |
| 106-C17A | 61.0 ± 8.7 (16.8) | 20.5 ± 3.2 (18.7) | 24.5 ± 3.8 (18.3) | 16.0 ± 3.4 (3.6) | 6.0 ± 1.9 (8.6) | 0.17 ± 0.03 (0.6) |
| 713 | 2.0 ± 0.3 (1.0) | 1.6 ± 0.3 (1.0) | 1.8 ± 0.2 (1.0) | 2.8 ± 0.4 (1.0) | 0.4 ± 0.1 (1.0) | 0.18 ± 0.01 (1.0) |
| 713-M3 | 50.2 ± 3.6 (24.9) | 7.1 ± 0.7 (4.6) | 10.1 ± 1.7 (5.5) | 21.8 ± 1.6 (7.9) | 3.0 ± 0.7 (8.0) | 0.18 ± 0.03 (1.0) |
a
Activity of the indicated antimicrobials against G. lamblia was determined as the EC50, the compound concentration (in μM) that inhibited growth of the parasite by 50% over the assay period. Data are means ± SEM of the results of 3 to 4 separate experiments. Ratios are relative to the mean EC50 of the respective parental isolate for each antimicrobial drug.