Table 2.
FabI mutations found in S. aureus mutant clones with reduced susceptibility to MUT056399
| S. aureus strain and clone | FabI mutation |
MIC (μg/ml) |
||
|---|---|---|---|---|
| Nucleotide mutation | Amino acid substitution | MUT056399 | Triclosan | |
| MSSA ATCC 29213 | ||||
| Wild type | 0.031 | 0.008 | ||
| 29213-399-2 | T611C | F204S | 1 | 0.5 |
| 29213-399-5 | A577T | I193F | 0.5 | 0.25 |
| MSSA ATCC 12600 | ||||
| Wild type | 0.031 | 0.016 | ||
| 12600-399-1 | T611C | F204S | 2 | 1 |
| 12600-399-16 | C284T | A95V | >32 | 2 |
| VISA ATCC 700699-V4 | ||||
| Wild type | 0.031 | 0.016 | ||
| 700699-399-17 | A577T | I193F | 4 | 1 |
| 700699-399-18 | C284T | A95V | >32 | 2 |
| MRSA Linr NRS 119a | ||||
| Wild type | 0.031 | 0.016 | ||
| 119-399-6 | T611C | F204S | 2 | 1 |
| 119-399-10 | C284T | A95V | >32 | 2 |
| MRSA NRS 384 (USA300) | ||||
| Wild type | 0.031 | 0.012 | ||
| 384-399-5 | T611C | F204S | 2 | 0.5 |
| 384-399-10 | C284T | A95V | >32 | 2 |
| MRSA NRS 385 (USA500) | ||||
| Wild type | 0.031 | 0.008 | ||
| 385-399-1 | T611C | F204S | 1 | 0.5 |
a
Linr, linezolid resistant.