Table 1.
Susceptibility testing and transmission electron microscopy results for Enterococcus faecium strains and their mutants
| Straina | MIC (μg/ml) |
Cell wall thickness ± SD (nm) | |
|---|---|---|---|
| Vancomycin | Daptomycin | ||
| VRE SF 12047 | >256 | 4 | 30.3 ± 5.5 |
| VRESF 12047 M | >256 | 64 | 43.5 ± 9.2 |
| VRE 12311 | >256 | 4 | 22.2 ± 4.5 |
| VRE 12311 M | >256 | 256 | 32.4 ± 5.2 |
| VRE ATCC 51559 | >256 | 2-4 | 24.9 ± 2.6 |
| VRE ATCC 51559 M | >256 | 128 | 39.5 ± 6.2 |
a
M, mutant recovered from pharmacodynamic sample at 168 h in model simulating daptomycin at 6 mg/kg every 24 h.