Table 2.
MICs of 150 strains against EMC120B12 and fluconazole
| Strain no. | Strain (n = 150)a | MIC (μg/ml) |
|
|---|---|---|---|
| EMC120B12 | Fluconazole | ||
| 1 | C. albicans ATCC 90028 | 4 | 2 |
| 2 | C. albicans DSMZ 11949 | 4 | 4 |
| 3 | C. glabrata ATCC 90030 | 16 | 16 |
| 4 | C. guilliermondii ATCC 90877 | 4 | 1 |
| 5 | C. parapsilosis ATCC 22019 | 0.125 | 0.25 |
| 6 | C. parapsilosis ATCC 90018 | 0.125 | 0.125 |
| 7 | Issatchenki orientalis ATCC 6258 | 0.25 | 0.5 |
| 8 | C. neoformans | 4 | 1 |
| 9 | C. albicans 1008* | 32 | 32 |
| 10 | C. albicans 75 | 0.25 | 0.5 |
| 11 | C. albicans 924* | 128 | 128 |
| 12 | C. albicans 931* | 64 | 64 |
| 13 | C. albicans 959* | 128 | 128 |
| 14 | C. albicans 971* | 8 | 32 |
| 15 | C. albicans 974* | 8 | 4 |
| 16 | C. albicans 987* | 16 | 32 |
| 17 | C. albicans 993* | 16 | 16 |
| 18 | C. albicans 994* | 32 | 64 |
| 19 | C. albicans 999* | 64 | 32 |
| 20 | C. albicans AM2001/0007 | 0.5 | 0.25 |
| 21 | C. albicans AN 10481 | 8 | 0.25 |
| 22 | C. albicans AN 10798 | 0.25 | 0.5 |
| 23 | C. albicans AN 10883 | 0.125 | 0.125 |
| 24 | C. albicans AN 11231 | 0.5 | 0.5 |
| 25 | C. albicans AN 11549 | 0.5 | 0.25 |
| 26 | C. albicans AN 13 | 0.125 | 0.125 |
| 27 | C. albicans AN 13244 | 0.125 | 0.125 |
| 28 | C. albicans AN 1699 | 8 | 32 |
| 29 | C. albicans AN 1769 | 0.25 | 0.25 |
| 30 | C. albicans AN 1994 | 128 | 16 |
| 31 | C. albicans AN 2787 | 0.125 | 0.125 |
| 32 | C. albicans AN 2829 | 4 | 64 |
| 33 | C. albicans AN 3156 | 8 | 16 |
| 34 | C. albicans AN 3431 | 0.125 | 0.125 |
| 35 | C. albicans AN 3591 | 0.125 | 0.125 |
| 36 | C. albicans AN 397 | 0.125 | 0.125 |
| 37 | C. albicans AN 4071 | 4 | 16 |
| 38 | C. albicans AN 4462.1 | 2 | 1 |
| 39 | C. albicans AN 4835 | 0.125 | 0.25 |
| 40 | C. albicans AN 562 | 1 | 16 |
| 41 | C. albicans AN 5752.2 | 0.125 | 0.25 |
| 42 | C. albicans AN 5944 | 0.25 | 0.25 |
| 43 | C. albicans AN 5960 | 0.125 | 0.125 |
| 44 | C. albicans AN 6160 | 0.25 | 0.25 |
| 45 | C. albicans AN 62 | 0.125 | 0.125 |
| 46 | C. albicans AN 6896 | 4 | 0.25 |
| 47 | C. albicans AN 7961 | 0.125 | 0.125 |
| 48 | C. albicans AN 8449 | 1 | 0.25 |
| 49 | C. albicans AN 8775 | 0.25 | 0.25 |
| 50 | C. albicans AN 9560 | 1 | 0.25 |
| 51 | C. albicans AN 9645 | 0.25 | 0.25 |
| 52 | C. albicans AN4051 | 2 | 0.5 |
| 53 | C. albicans CA 20 | 0.125 | 0.125 |
| 54 | C. albicans CA 21 | 0.125 | 0.125 |
| 55 | C. albicans Jg 32570 | 128 | 16 |
| 56 | C. albicans MY 2902/2008 | 0.5 | 16 |
| 57 | C. albicans RU IV | 1 | 1 |
| 58 | C. albicans SCS 71865L | 0.125 | 64 |
| 59 | C. albicans VB 1723 | 4 | 0.5 |
| 60 | C. albicans VB 1723 | 0.5 | 0.25 |
| 61 | C. albicans VB 1811 | 0.125 | 0.125 |
| 62 | C. albicans VB 21064 | 0.125 | 0.125 |
| 63 | C. albicans VB 22905 | 0.25 | 0.125 |
| 64 | C. albicans VB 2688 | 0.125 | 0.125 |
| 65 | C. albicans VB 4384 | 2 | 0.5 |
| 66 | C. albicans VB 4606 | 0.125 | 0.125 |
| 67 | C. albicans VB 8567 | 0.125 | 0.125 |
| 68 | C. blankii VB 13063 | 0.5 | 32 |
| 69 | C. glabrata AN 10767 | 0.5 | 8 |
| 70 | C. glabrata AN 12749 | 0.25 | 8 |
| 71 | C. glabrata AN 12862 | 0.25 | 4 |
| 72 | C. glabrata AN 1857 | 1 | 2 |
| 73 | C. glabrata AN 4355 | 16 | 64 |
| 74 | C. glabrata AN 4462.2 | 0.125 | 0.125 |
| 75 | C. glabrata AN 5547 | 0.125 | 4 |
| 76 | C. glabrata AN 8148 | 0.25 | 4 |
| 77 | C. glabrata AN 8626 | 4 | 0.125 |
| 78 | C. glabrata CG 7 | 4 | 2 |
| 79 | C. glabrata VB 3346 | 4 | 64 |
| 80 | C. guilliermondii AN 444 | 0.5 | 4 |
| 81 | C. guilliermondii AN 6494 | 0.25 | 0.5 |
| 82 | C. guilliermondii AN 8832 | 4 | 2 |
| 83 | C. guilliermondii RU II | 4 | 2 |
| 84 | C. krusei 224 | 0.25 | 8 |
| 85 | C. krusei 394 | 4 | 16 |
| 86 | C. krusei 201 | 1 | 32 |
| 87 | C. krusei 222 | 1 | 16 |
| 88 | C. krusei 232 | 2 | 32 |
| 89 | C. krusei 237 | 2 | 32 |
| 90 | C. krusei 241 | 2 | 32 |
| 91 | C. krusei 242 | 1 | 32 |
| 92 | C. krusei 2572 | 2 | 32 |
| 93 | C. krusei 337 | 2 | 32 |
| 94 | C. krusei 364 | 1 | 32 |
| 95 | C. krusei 39.986 | 2 | 32 |
| 96 | C. krusei 639 | 1 | 32 |
| 97 | C. krusei A 1934 | 2 | 32 |
| 98 | C. krusei AN 12026 | 2 | 16 |
| 99 | C. krusei AN 2572 | 1 | 16 |
| 100 | C. krusei AN 2944 | 4 | 32 |
| 101 | C. krusei AN 4557 | 2 | 32 |
| 102 | C. krusei AN 8033 | 8 | 64 |
| 103 | C. krusei AN 8829 | 4 | 32 |
| 104 | C. krusei VB 18175 | 2 | 32 |
| 105 | C. lusitaniae AN 5752.1 | 0.125 | 0.25 |
| 106 | C. lusitaniae AN 6110.2 | 0.125 | 0.25 |
| 107 | C. lusitaniae UR 14911 | 0.5 | 8 |
| 108 | C. nivariensis RU IV | 0.125 | 4 |
| 109 | C. parapsilosis 352 | 2 | 16 |
| 110 | C. parapsilosis 551 | 1 | 0.25 |
| 111 | C. parapsilosis 553 | 0.5 | 0.25 |
| 112 | C. parapsilosis 619 St-R | 1 | 0.5 |
| 113 | C. parapsilosis St-R 623 | 0.5 | 0.25 |
| 114 | C. parapsilosis 1007.2 | 1 | 0.25 |
| 115 | C. parapsilosis 10207 | 1 | 0.5 |
| 116 | C. parapsilosis 10267 | 8 | 2 |
| 117 | C. parapsilosis 4321 | 1 | 0.25 |
| 118 | C. parapsilosis 549 | 2 | 1 |
| 119 | C. parapsilosis 552 | 2 | 0.5 |
| 120 | C. parapsilosis 554 | 2 | 0.25 |
| 121 | C. parapsilosis 640 | 2 | 0.25 |
| 122 | C. parapsilosis AN 1.5845 | 0.5 | 0.5 |
| 123 | C. parapsilosis AN 1.6464 | 0.5 | 0.25 |
| 124 | C. parapsilosis AN 11805 | 0.5 | 0.125 |
| 125 | C. parapsilosis AN 3.7441 | 0.5 | 0.5 |
| 126 | C. parapsilosis AN 3284 | 2 | 0.25 |
| 127 | C. parapsilosis AN 3570 | 0.5 | 0.25 |
| 128 | C. parapsilosis AN 39207 | 0.25 | 0.25 |
| 129 | C. parapsilosis AN 5485 | 0.25 | 1 |
| 130 | C. parapsilosis AN 6218 | 1 | 0.25 |
| 131 | C. parapsilosis AN 6480 | 0.5 | 0.5 |
| 132 | C. parapsilosis AN 7348 | 2 | 0.5 |
| 133 | C. parapsilosis AN 7793 | 2 | 0.5 |
| 134 | C. parapsilosis AN 7903 | 0.125 | 0.25 |
| 135 | C. parapsilosis AV 7675 | 2 | 8 |
| 136 | C. parapsilosis R V II | 4 | 0.5 |
| 137 | C. parapsilosis St-R 613 | 2 | 0.5 |
| 138 | C. parapsilosis UR 13926 | 0.125 | 0.125 |
| 139 | C. parapsilosis UR 2795V | 0.5 | 0.25 |
| 140 | C. parapsilosis UR 5428 | 0.5 | 0.25 |
| 141 | C. parapsilosis VA 9625 | 1 | 0.25 |
| 142 | C. parapsilosis VB 4188 | 1 | 0.5 |
| 143 | C. pelliculosa AN 3525 | 16 | 8 |
| 144 | C. pelliculosa AN 8197 | 16 | 16 |
| 145 | C. tropicalis 550 | 0.5 | 0.25 |
| 146 | C. tropicalis AN 1946 | 128 | 4 |
| 147 | C. tropicalis AN 3241 | 0.25 | 0.5 |
| 148 | C. tropicalis AN 4522.1 | 0.125 | 0.125 |
| 149 | C. tropicalis AN 4572 | 2 | 1 |
| 150 | C. tropicalis UR 15464 | 0.125 | 0.125 |
a
Strains identified to be resistant to fluconazole with preliminary characterization on resistance mechanisms are identified with asterisks (see Discussion). These strains have been provided by the National Reference Center for Systemic Mycoses, as have strains 10, 84 to 96, and 109 to 121. All other strains were provided by the strain collection of the Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen.