Table 3.

Coefficients of determination and magnitudes of the most correlated PK/PD index, as determined in the default setting, required for a bacteriostatic or bactericidal effect^a

Simulation setting	Benzylpenicillin					Cefuroxime					Erythromycin					Gentamicin					Moxifloxacin					Vancomycin
	R2			fT>MIC		R2			fT>MIC		R2			fAUC/MIC		R2			fAUC/MIC		R2			fAUC/MIC		R2			fAUC/MIC
	fCmax/MIC	fAUC/MIC	fT>MIC	Bstat (%)	Bcid (%)	fCmax/MIC	fAUC/MIC	fT>MIC	Bstat (%)	Bcid (%)	fCmax/MIC	fAUC/MIC	fT>MIC	Bstat	Bcid	fCmax/MIC	fAUC/MIC	fT>MIC	Bstat	Bcid	fCmax/MIC	fAUC/MIC	fT>MIC	Bstat	Bcid	fCmax/MIC	fAUC/MIC	fT>MIC	Bstat	Bcid
Default	0.54	0.84	0.93*	29	38	0.72	0.90	0.96*	30	41	0.78	0.93*	0.90	11	34	0.70	0.92*	NA	39	67	0.93	0.99*	0.94	11	19	0.90	0.99*	NA	54	NA
i (a) Reduced CL	0.73	0.94*	0.93	25	33	0.89	0.99*	0.98	17	21	0.93	1.0*	0.91	8.5	19	0.86	0.98*	NA	28	42	0.97	0.99*	NA	11	19	0.93	0.99*	NA	51	NA
(b) PK neonate	0.86	0.98*	0.91	24	32											0.91	0.99*	NA	26	37
ii (a) 0.5× MIC	0.54	0.84	0.98*	40	52	0.72	0.90	0.98*	45	56	0.78	0.93	0.96*	22	67	0.71	0.92*	NA	79	133	0.93	0.99*	0.98	23	37	0.90	0.99*	NA	109	NA
2× MIC	0.54	0.84	0.88*	20	26	0.72	0.90*	0.87	15	31	0.78	0.93*	0.80	5.5	17	0.71	0.92	0.94*	20	33	0.93	0.99*	0.85	5.7	9.4	0.90	0.99*	NA	27	NA
(b) Calculated MIC	0.54	0.84	0.99*	45	58	0.72	0.90	0.98*	46	57	0.78	0.93	0.94*	51	155	0.71	0.92*	NA	64	109	0.93	0.99*	0.98	26	42	0.90	0.99*	NA	37	NA
(c) EC50	0.54	0.84	0.99*	42	55	0.72	0.90	0.98*	46	57	0.78	0.93	0.97*	41	125	0.71	0.92*	0.88	8	14	0.93	0.99*	0.97	19	31	0.90	0.99*	NA	45	NA
iii (a) log10 CFU/ml (12 h)	0.66	0.92	0.94*	14	25	0.85	0.98*	0.98*	13	27	0.93	1.0*	0.92	5.1	32	0.80	0.94*	NA	8	21	0.96	0.99*	0.94	6	13	0.91	0.99*	NA	29	NA
log10 CFU/ml (48 h)	0.53	0.82	0.93*	28	33	0.71	0.89	0.96*	28	35	0.76	0.92*	0.88	8.8	19	0.73	0.94*	NA	51	70	0.92	0.99*	0.92	9.3	14	0.90	0.99*	NA	42	66
log10 CFU/ml (240 h)	0.52	0.80	0.90*	27	29	0.67	0.86	0.92*	26	30	0.73	0.90*	0.80	6.9	9.3	0.75	0.96*	NA	57	68	0.84*	NA	NA	NA	NA	0.86	0.98*	NA	39	41
(b) AUBC24	0.68	0.94*	0.94*			0.86	0.99*	0.98			0.92	1.0*	0.92			0.82	0.97*	NA			0.97	0.99*	0.94			0.93	0.99*	NA
AUBC48	0.62	0.90	0.94*			0.80	0.96	0.98*			0.86	0.98*	0.91			0.78	0.95*	NA			0.95	0.99*	0.94			0.92	0.99*	NA
(c) T99%	0.63	0.91	0.94*			0.81	0.97	0.99*			0.88	0.99*	0.96			0.79	0.95*	0.95*			0.96	0.98*	0.96			0.87	0.98*	NA
T99.9%	0.61	0.90	0.96*			0.80	0.97	0.98*			0.85	0.98*	0.95			0.75	0.94	0.96*			0.96	0.97*	0.93			NA	NA	NA
T99.99%	0.58	0.87	0.97*			0.76	0.94	0.99*			0.83	0.95*	NA			0.71	0.92	0.97*			0.92	0.93*	NA			NA	NA	NA
iv CP1 driving PD	0.60	0.84	0.93*	31	38	0.82	0.93	0.97*	37	41	0.86	0.95*	0.89	10	32	0.94	0.98*	NA	26	39	0.96	0.97*	NA	12	34	0.96	0.98*	NA	50	NA
CP2 driving PD	0.87	0.96*	0.92	32	38											0.97	0.99*	NA	23	33

^aRoman numerals and italic letters refer to sections in the text (see “Altered simulation settings” in Materials and Methods and in Results).

^*, the PK/PD index with the best correlation (highest R²) to the PD endpoint; NA, not estimable.