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. 2011 Oct;55(10):4537–4542. doi: 10.1128/AAC.00713-11

Fig. 2.

Fig. 2.

Distribution of total vancomycin in the tissues of CF-1 mice following intravenous administration of a dose (5 mg/kg) of standard vancomycin solution (SV), conventional liposomal vancomycin (CLV), and PEGylated liposomal vancomycin (PLV). (A) Spleen. **, P < 0.001 for conventional liposomes versus standard vancomycin at 5 min; ++, P < 0.001 for PEGylated liposomes versus standard vancomycin at 5 min; *, P < 0.01 for conventional liposomes versus standard vancomycin at 1 h; +, P < 0.01 for PEGylated liposomes versus standard vancomycin at 1 h. (B) Liver. **, P < 0.001 for conventional liposomes versus standard vancomycin at 5 min; ++, P < 0.001 for PEGylated liposomes versus standard vancomycin at 5 min; *, P < 0.01 for conventional liposomes versus standard vancomycin at 1 h; +, P < 0.01 for PEGylated liposomes versus standard vancomycin at 1 h. (C) Lung. **, P < 0.001 for conventional liposomes versus standard vancomycin at 5 min; ++, P < 0.001 for PEGylated liposomes versus standard vancomycin at 5 min; *, P < 0.01 for conventional liposomes versus standard vancomycin at 1 h; +, P < 0.01 for PEGylated liposomes versus standard vancomycin at 1 h. (D) Kidney. **, P < 0.001 for conventional liposomes versus standard vancomycin at 5 min; ++, P < 0.001 for PEGylated liposomes versus standard vancomycin at 5 min; *, P < 0.01 for conventional liposomes versus standard vancomycin at 1 h; +, P < 0.01 for PEGylated liposomes versus standard vancomycin at 1 h.