Table 1.
Main pharmacokinetic parameters of vancomycin in plasma after intravenous administration of a dose (5-mg/kg) of standard, conventional, and PEGylated liposomal vancomycin formulationsa
| Vancomycin formulation | Cmax (μg/ml) | AUC0-48 (μg · h/ml) | CL (ml/h) |
|---|---|---|---|
| SV | 6.8 ± 0.4 | 6.8 ± 0.3 | 18.3 ± 0.7 |
| CLV | 9.8 ± 1.1* | 25.9 ± 2.8*** | 4.9 ± 0.6*** |
| PLV | 15.5 ± 1.7** | 47.2 ± 2.4*** | 2.7 ± 0.1*** |
a
SV, standard formulation; CLV, conventional formulation; PLV, PEGylated formulation.
Symbols *, **, and *** denote P values of <0.05, 0.01, and 0.001, respectively, versus parameters for the standard solution.