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. 2011 Oct;55(10):4774–4781. doi: 10.1128/AAC.00151-11

Fig. 3.

Fig. 3.

DPP-1 prolongs incubation time in scrapie-infected mice after oral treatment. (A) Oral treatment. Kaplan-Meier survival analysis of i.p. scrapie-infected Tga20 mice was performed after oral treatment with DPP-1 or benzothiazol (BTD). The treatment groups included untreated controls (▾), NaCl controls (▴), benzothiazol (BTD)-treated mice (●), and DPP-1-treated mice (■). (B) Mean survival times in primary efficiency test ± the standard deviation. Comparison of DPP-1 versus untreated controls, NaCl controls, and BTD-treated mice was carried out by using the log-rank test (*, P < 0.05). (C) Oral prophylaxis. Kaplan-Meier survival analysis of i.p. scrapie-infected C57BL/6 mice was performed after oral treatment with DPP-1. The treatment groups included untreated controls (▾), NaCl controls (▴) and DPP-1-treated mice (■). (D) Mean survival times in oral prophylaxis ± the standard deviation. Comparison of DPP-1-treated versus untreated controls and NaCl controls was carried out by using the log-rank test (**, P < 0.01).