Table 1.
In vitro antifungal activities of E1210 against Candida spp. and Aspergillus fumigatus
| Organism (no. of strains) | Compound | MIC (μg/ml) |
||
|---|---|---|---|---|
| Range | MIC50 | MIC90 | ||
| Candida albicans (52) | E1210 | ≤0.008–0.016 | ≤0.008 | ≤0.008 |
| Fluconazole | ≤0.06–>64 | 0.13 | 0.25 | |
| Itraconazole | 0.008–>4 | 0.016 | 0.016 | |
| Voriconazole | ≤0.004–>4 | ≤0.004 | ≤0.004 | |
| Amphotericin B | 0.25–0.5 | 0.25 | 0.5 | |
| Micafungin | 0.008–0.03 | 0.016 | 0.016 | |
| Candida glabrata (44) | E1210 | ≤0.008–0.06 | 0.06 | 0.06 |
| Fluconazole | 4–32 | 4 | 16 | |
| Itraconazole | 0.25–2 | 0.5 | 1 | |
| Voriconazole | 0.06–1 | 0.13 | 0.25 | |
| Amphotericin B | 0.13–1 | 1 | 1 | |
| Micafungin | 0.008–0.03 | 0.03 | 0.03 | |
| Candida tropicalis (23) | E1210 | ≤0.008–0.03 | 0.016 | 0.03 |
| Fluconazole | 1–>64 | >64 | >64 | |
| Itraconazole | 0.03–>4 | 1 | >4 | |
| Voriconazole | 0.03–>4 | >4 | >4 | |
| Amphotericin B | 0.25–0.5 | 0.5 | 0.5 | |
| Micafungin | 0.016 | 0.016 | 0.016 | |
| Candida parapsilosis (26) | E1210 | ≤0.008–0.016 | ≤0.008 | 0.016 |
| Fluconazole | 0.13–1 | 0.5 | 1 | |
| Itraconazole | 0.03–0.25 | 0.13 | 0.13 | |
| Voriconazole | ≤0.004–0.03 | 0.016 | 0.016 | |
| Amphotericin B | 0.5 | 0.5 | 0.5 | |
| Micafungin | 0.13–1 | 1 | 1 | |
| Aspergillus fumigatus (20) | E1210 | 0.03–0.13 | 0.06 | 0.13 |
| Fluconazole | >64 | >64 | >64 | |
| Itraconazole | 0.5 | 0.5 | 0.5 | |
| Voriconazole | 0.13–0.5 | 0.25 | 0.5 | |
| Amphotericin B | 0.25–1 | 0.5 | 0.5 | |
| Micafungin | 0.008–0.06 | 0.03 | 0.06 | |