Table 3.
In vitro antifungal activities of E1210 against fluconazole-sensitive and fluconazole-resistant Candida spp.
| Fluconazole susceptibility of Candida spp. (no. of strains) | Compound | MIC (μg/ml) |
||
|---|---|---|---|---|
| Range | MIC50 | MIC90 | ||
| Susceptible (140) | E1210 | ≤0.008–4 | ≤0.008 | 0.06 |
| Fluconazole | ≤0.06–32 | 0.5 | 8 | |
| Itraconazole | 0.008–4 | 0.13 | 0.5 | |
| Voriconazole | ≤0.004–>4 | 0.016 | 0.13 | |
| Amphotericin B | 0.13–1 | 0.5 | 1 | |
| Micafungin | 0.008–1 | 0.016 | 1 | |
| Resistant (18) | E1210 | ≤0.008–>32 | 0.016 | 0.03 |
| Fluconazole | 64–>64 | >64 | >64 | |
| Itraconazole | 0.06–>4 | 2 | >4 | |
| Voriconazole | 0.03–>4 | >4 | >4 | |
| Amphotericin B | 0.25–1 | 0.5 | 0.5 | |
| Micafungin | 0.008–0.13 | 0.016 | 0.03 | |