Fig. 5.

In silico humanization of the murine pharmacokinetics and predicted pharmacodynamic response obtained from the mathematical model. The administration of 100, 200, 400, and 800 mg micafungin to a so-called average human results in a micafungin concentration-time profile represented by the solid line. For the pharmacodynamics, the fungal burden without therapy is shown by the dotted line, and the predicted response with each dosage is shown by the solid line.