Table 2.
Measures of central tendency and standard deviations for the parameter values from the mathematical model for each echinocandin against Candida glabrata
| Parametera | Result for: |
|||||
|---|---|---|---|---|---|---|
| Micafungin |
Anidulafungin |
Caspofungin |
||||
| Mean | SD | Mean | SD | Median | SD | |
| ka (h−1) | 26.83 | 4.92 | 20.35 | 2.21 | 24.78 | 3.11 |
| CLS (liter/h) | 0.0005 | 0.0002 | 0.0009 | 0.0003 | 0.0004 | 0.0003 |
| Vc (liter) | 0.004 | 0.0007 | 0.027 | 0.0077 | 0.0031 | 0.002 |
| kcp (h−1) | 7.65 | 9.73 | 22.73 | 12.38 | 26.97 | 12.45 |
| kpc (h−1) | 20.4 | 5.59 | 19.27 | 3.01 | 16.79 | 5.48 |
| kck (h−1) | 18.94 | 10.48 | 21.05 | 6.24 | 6.7 | 8.55 |
| kkc (h−1) | 12.88 | 4.32 | 26.37 | 4.34 | 2.12 | 9.34 |
| Vkidney(liter) | 0.005 | 0.004 | 0.014 | 0.006 | 0.009 | 0.003 |
| Kgmax (log10 CFU/g/h) | 0.06 | 0.01 | 0.05 | 0.003 | 0.062 | 0.024 |
| Hg | 6.30 | 1.75 | 4.64 | 3.03 | 6.34 | 1.87 |
| C50g (mg/liter) | 0.464 | 0.27 | 1.74 | 0.57 | 0.59 | 0.9 |
| POPmax (CFU/g) | 678,931 | 335,816 | 6,076,970 | 3,145,520 | 916,159 | 3,821,240 |
| Kkmax (log10 CFU/g/h) | 0.089 | 0.029 | 0.1 | 0.059 | 0.059 | 0.054 |
| Hk | 2.4 | 1.81 | 2.72 | 2.63 | 1.47 | 1.36 |
| C50k (mg/liter) | 25.82 | 7.81 | 19.42 | 8.14 | 13.82 | 5.17 |
| Initial condition (CFU/g) | 4,926 | 1,579 | 5,590 | 1,594 | 2,437 | 1,324 |
a
Parameters are defined in Materials and Methods.