Table 2.
Nucleotide and amino acid identities of the new Vga(E) determinant compared with related Vga determinants that confer resistance to streptogramins A, pleuromutilins, and lincosamides
| Determinant | GenBank accession no. | % identitya |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Vga(A) |
Vga(A)LC |
Vga(A)v |
Vga(B) |
Vga(C) |
Vga(D) |
Vga(E) |
|||||||||
| nt | aa | nt | aa | nt | aa | nt | aa | nt | aa | nt | aa | nt | aa | ||
| Vga(A) | M90056 | 100 | 100 | 99 | 99 | 83 | 81 | 57 | 46 | 66 | 64 | 57 | 48 | 63 | 53 |
| Vga(A)LC | DQ823382 | 100 | 100 | 83 | 81 | 59 | 45 | 67 | 63 | 60 | 48 | 64 | 53 | ||
| Vga(A)v | AF186237 | 100 | 100 | 55 | 45 | 67 | 66 | 58 | 50 | 63 | 54 | ||||
| Vga(B) | U82085 | 100 | 100 | 56 | 45 | 61 | 53 | 53 | 41 | ||||||
| Vga(C) | FN377602 | 100 | 100 | 56 | 53 | 61 | 55 | ||||||||
| Vga(D) | GQ205627 | 100 | 100 | 57 | 48 | ||||||||||
| Vga(E) | FR772051 | 100 | 100 | ||||||||||||
a
Sequence alignment was performed with EMBOSS pairwise alignment algorithms (http://www.ebi.ac.uk/Tools/emboss/align/; needle global alignment of two sequences [matrices were Blosum62 for proteins and DNAfull for DNA; open gap penalty, 10.0; gap extension penalty, 0.5]). nt, nucleotides.