Table 2.
Ribosomal susceptibility to tuberactinomycin-induced inhibition of protein synthesis
| Type of ribosomes | IC50 (μM) ofa: |
|
|---|---|---|
| Viomycin | Capreomycin | |
| M. smegmatis bacterial | 0.03 ± 0.0057 | 0.03 ± 0.017 |
| Rabbit reticulocyte | 80 ± 12.6 | 50 ± 4.5 |
| Cytohybrid (cyt14) | 16 ± 0.6 | 52 ± 11.7 |
| 1408G/1491A (cyt2) | 53 ± 4.0 | 110 ± 5.8 |
| Mitohybrid (mit13) | 45 ± 5.8 | 75 ± 10.4 |
| A1555G mutant mitohybrid | 11 ± 2.1 | 13 ± 1.1 |
| C1494U mutant mitohybrid | 12 ± 1.7 | 23 ± 4.0 |
a
Drug concentrations required to inhibit synthesis of active luciferase to 50% (IC50).