Table 4.

Factors associated with viral load changes after MCT^a

Characteristic	Changes in VL after MCT
	Bivariate analysis		Multivariate analysis
	P	B (95% CIb)	P	B (95% CI)
Male sex	0.698	−0.118 (−0.727 to 0.491)	NAc
Age	0.961	0.000 (−0.019 to 0.018)	NA
Treatment naïve	0.297	0.302 (−0.273 to 0.877)	NA
Sexual transmission	0.022	0.469 (0.042 to 0.897)	0.672	0.077 (−0.286 to 0.440)
IDUd transmission	0.205	−0.289 (−0.742 to 0.164)	NA
Time since diagnosis	0.169	−0.021 (−0.050 to 0.009)	NA
HCV PCR+e	0.243	−0.289 (−0.779 to 0.202)	NA
CD4+ counts (cells/ml)	0.001	0.002 (0.001 to 0.003)	0.346	0.001 (−0.001 to 0.002)
Plasma log VL	0.523	−0.120 (−0.497 to 0.256)	NA
LogX4VLf (HIV RNA Copies/ml)	<0.0001	−0.263 (−0.338 to −0.187)	<0.0001	−0.234 (−0.322 to −0.146)
LogR5VLg (HIV RNA Copies/ml)	0.227	−0.089 (−0.253 to 0.074)	NA

^aIn this analysis, only patients with X4- and R5-tropic virus levels available and with >1,000 HIV RNA copies/ml were included (n = 51). Bivariate and multivariate analyses were performed using a linear regression model, and variables showing a P value of <0.1 in the bivariate analysis were included in the multivariate analysis. In the multivariate analysis, variables with a P value of <0.05 were considered statistically significant.

^bB, regression coefficient; CI, confidence interval.

^cNot applicable.

^dIDU, injecting drug user.

^ePCR⁺, PCR positive for hepatitis C virus.

^fNumber of HIV RNA copies/ml in the U87-CXCR4 cell line well supernatant.

^gNumber of HIV RNA copies/ml in the U87-CCR5 cell line well supernatant.