Table 2.
Clinical outcomes for subjects in cohort 1a
| Outcome | Group A (n = 5) | Group B (n = 4) | Group C (n = 5) | Group D (n = 5) |
|---|---|---|---|---|
| No. with diarrhea (%) | 5 (100) | 4 (100) | 4 (80) | 4 (80) |
| No. with moderate or severe diarrhea (%) | 4 (80) | 4 (100) | 4 (80) | 4 (80) |
| Mean [median] incubation period (hr) (range) | 43 [44] (32–51) | 42 [43] (35–48) | 43 [40] (21–69) | 57 [55] (45–71) |
| Mean [median] diarrhea stool output in 24-hour period (g) (range) | 966 [669] (383–2,418) | 765 [476] (419–1,687) | 1,032 [1,134] (350–1,511) | 666 [613] (473–966) |
| Mean [median] diarrhea total stool output (g) (range) | 1,106 [793] (719–2,418) | 1,359 [1,051] (448–2,886) | 1,707 [1,709] (1,271–2,138) | 1,021 [932] (749–1,472) |
| Mean [median] duration of diarrhea (hr) (range) | 36 [37] (12–61) | 57 [59] (4–107) | 86 [88] (23–143) | 52 [55] (28–71) |
| Mean [median] of the maximum no. of stools in 24 h (range) | 9 [6] (3–19) | 6 [6] (3–9) | 6 [6] (4–7) | 5 [5] (3–7) |
| No. of subjects with fever | 1 | 2 | 1 | 0 |
| No. of subjects with vomiting (maximum no. of vomiting episodes) | 1 (4) | 1 (4) | 1 (5) | 3 (5) |
a
Group A, 2 × 108 CFU with bicarbonate; group B, 2 × 108 CFU with CeraVacx; group C, 2 × 107 CFU with bicarbonate; group D, 2 × 107 CFU with CeraVacx.