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Protective efficacy of HSV-2 gB and gD antigens in a mouse genital model. Six- to 8-week-old female BALB/c mice were vaccinated by intramuscular injection with either 20 μg of gD (A and B) or 20 μg of gB (C and D) protein on days 0 and 28. On day 62, the mice were infected via the intravaginal route with either 104 PFU (A and C) or 105 PFU (B and D) of HSV-2 333. Following infection, the mice were scored daily for 14 days. The error bars indicate standard deviations.
