Table 1.
Comparison of disease in mice vaccinated with gB-gD/CPG and gD/MPL and challenged with HSV-2a
| Antigen | Avg wt loss (g/day)b | P valuec | % Mortality (n = 10) | % Disease symptoms |
|---|---|---|---|---|
| Naive | −0.60 | 62.5 | ||
| CPG/alum | −0.71 | 0.5558 | 50.0 | 100 |
| MPL/alum | −0.73 | 0.5031 | 87.5 | 100 |
| gD/MPL/alum | +0.08 (gain) | 0.0005 | 0.00 | 12.5 |
| gB-gD/CPG/alum | +0.10 (gain) | 0.0004 | 0.00 | 0 |
a
Mice were immunized at weeks 0 and 4 and challenged with 106 PFU HSV-2 by the intranasal route at week 6.
b
Mean estimated slope of the weight loss between days 5 and 14 postchallenge.
c
P values were calculated on differences between weight loss in vaccinated and naive animals at a given HSV-2 dose.