Table 3.

Weight loss and mortality in male guinea pigs vaccinated with gB+gD/CPG/alum or gD/MPL/alum and challenged with HSV-2^a

Antigen	Avg wt loss (g/day)a	P valuec	% Mortality (n = 6)
Naive	−9.19		50
gB-gD/CPG/alum	3.05	<0.0001	0
gD/MPL/alum	3.06	<0.0001	0

^aMale guinea pigs (n = 6) were immunized on days 0 and 28. Two weeks after the last boost, the guinea pigs were challenged with10⁵ PFU of HSV-2.

^bMean estimated slope of the weight loss between days 5 and 14 postchallenge.

^cP values were calculated on differences between weight loss in vaccinated and naive animals at a given HSV-2 dose.