Table 1.
Functional groups enriched in our screen
| Category and function (P value)a | Genes |
|---|---|
| Protein fate (folding, modification, and destination) (9.9E−12) | |
| Modification by phosphorylation, dephosphorylation, and autophosphorylation (3.71E−6) | |
| Protein kinases | SAT4/HAL4, HAL5, PTK2, SKY1, HRK1, PHO85, RTK1 |
| Protein phosphatases | PTC1, SIT4, SAP185, SAP155, PPZ1, YVH1, REG1, RTS1 |
| Cellular transport, transport facilities, and transport routes (3.7E−09) | |
| Vesicular transport (Golgi network, etc.) (2.27E−16) | |
| TRAPP complex | KRE11, GSG1 |
| GARP complex | VPS52, VPS54, VPS51 |
| Membrane-associated retromer complex | VPS29, VPS35, PEP8 |
| CORVET and HOPS complexes | PEP3, PEP5, VPS16, VAM6, VPS41 |
| SNARE proteins | VAM7, SEC22, GOS1, TLG2, PEP12, VAM3 |
| Oligomeric Golgi complex | COG7, COG8, COG6, COG5, RUD3, SNC2 |
| Other proteins related to the Golgi network | VPS15, VPS34, ARL1, ARF1, SYS1, YPT6, GCS1, ERV14, LST7, VPS1 |
| Cell cycle and DNA processing (3.0E−07) | |
| DNA conformation modification (e.g., chromatin) (1.5E−05) | |
| ADA/SAGA/SLIK remodeling complex | GCN5, SPT7, HFI1, SPT20, SGF29, ADA2, NGG1, SGF11, UBP8, DST1 |
| SWR complex | ARP6, SWC5, SWC3, VPS71, HTZ1, VPS72 |
| RSC chromatin-remodeling complex | NPL6, HTL1, RSC1, RSC2, LDB7 |
| Transcription (3.4E−03) | |
| Transcriptional control (2.2E−03) | |
| RNA polymerase II mediator complex | SRB5, MED2, SOH1, MED1, CSE2 |
| Other RNA polymerase II-associated proteins | PAF1, RTF1, RPB9, HPR1, RPB4 |
| Transcription cofactors and related proteins | SWI6, THP1, TAF14, SWI3 |
| Phosphorylation of the RNA polymerase II C-terminal domain | CTK2, SSN3 |
a
The P value reflects the probability that the observed annotation of the particular GO term to a group of genes occurs by chance.