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Functions of Sir proteins. (A) The silencer binding proteins ORC, Rap1 (R), and Abf1 (A) recruit the Sir proteins (1 to 4) to the silencer. Sir2 deacetylates neighboring nucleosomes, generating binding sites for Sir3 and Sir4. Reiterations of this cycle enable spreading. (B) Conserved domains of the four Sir proteins in S. cerevisiae are indicated. For each protein, the names of paralogs are listed.
