Fig. 1.

Genome-wide expression changes in strains carrying evolved alleles. (A) Genome-wide expression profiles of strains carrying the evolved alleles PMA1e MKT1e, MKT1e, MDS3e MKT1e, and MDS3e grown in a low-glucose environment. Red represents genes that are induced, and green represents those that are repressed, relative to the mean expression levels in the progenitor strain (no evolved alleles) under the same conditions. (B) Genes with high expression specific for MKT1e are enriched for Puf3 targets. The blue bar indicates genes in the Puf3 module. Genes are reordered by membership in the Puf3 module.