Table 3.
Profile of the molecules that underwent the greatest change in the stomach for LG21-associated gnotobiotic mice vs GF mice as determined by a microarray analysis
| Gene | Log2 fold change |
Gene reference | ||
|---|---|---|---|---|
| 1st expt | 2nd expt | Avg | ||
| Downregulated genes | ||||
| Gastrin | −5.4 | −3.2 | −4.3 | NM010257.1 |
| Potassium voltage channel (Kcne 3) | −3.1 | −2.7 | −2.9 | NM020574.1 |
| Chloride channel calcium activated 3 | −2.6 | −2.9 | −2.8 | NM017474 |
| Secreted phosphoprotein 1 | −3.6 | −1.9 | −2.8 | NM009263.1 |
| Fatty acid binding protein 2 | −2.4 | −2.4 | −2.4 | NM007980.1 |
| Embryo whole-body cDNA | −2.8 | −1.9 | −2.4 | AK004474.1 |
| 6 BAC RP24-180C9 | −2.6 | −1.8 | −2.2 | |
| Adult male small intestine cDNA | −2.5 | −1.8 | −2.2 | AK008023.1 |
| DNA segment, chromasome 15 | −2.2 | −2.0 | −2.1 | BC010337.1 |
| Claudin 7 | −2.0 | −2.1 | −2.1 | BC008104.1 |
| Upregulated genes | ||||
| Nebulin | 5.1 | 2.4 | 3.8 | AY189120 |
| Mast cell protease 1 | 3.6 | 2.6 | 3.1 | NM008570.1 |
| Weakly similar to V-ATPase | 4.6 | 1.5 | 3.1 | AV204216 |
| Chromosome 1 | 1.0 | 4.3 | 2.7 | |
| Troponic C | 2.6 | 2.6 | 2.6 | NM009394.1 |
| Myosin heavy chain IIX | 2.5 | 2.4 | 2.5 | AJ293626.1 |
| Hydroxysteroid 17-β dehydrogenase | 1.1 | 3.6 | 2.4 | NM030611.1 |
| Myosin heavy chain 2X | 2.3 | 2.4 | 2.4 | AJ002522. |
| Adult male stomach cDNA | 2.0 | 2.5 | 2.3 | AK008863.1 |
| Myosin heavy polypeptide 8 | 2.4 | 2.1 | 2.3 | BB011213 |