Figure 2.
Clodronate treatment reduces macrophage load and improves renal function. Cystic kidneys from Pkd1fl/fl;Pkhd1-Cre mice treated with LC show (B) fewer F4/80+ macrophages (arrows) along the cyst-lining cells compared with LV-treated mouse kidneys (A, arrows). (C) Scan of a sagittal section of a representative kidney from LV- and LC-treated mice, respectively, shows (D) better-preserved parenchyma in LC-treated mice and lowered cystic index, (E) improved kidney/body weight ratio, and (F) significantly improved renal BUN values. A, B: Green, F4/80; Red, DBA. *P < 0.01; **P < 0.001.