Fig. 2.

Residues examined. (Left) Residues in the vestibule. Shown is the structure of the vestibule (yellow triangle), between two protomers of model 2DRD (6), in red and green. (Right) Residues in the central cavity (S462 is behind the G97 residue and is not visible). The protein is shown in a mesh representation and corresponds to access (red), binding (blue), and extrusion (green) protomers of model 2DRD. The yellow lines show the approximate position of the central cavity, with the proximal part of the model cut off to reveal the examined residues (in space-filling models).