Fig. 1.
IRF3 KO mice resolve a primary infection equivalent to that in WT mice despite elevated chlamydial burdens at early time points. (A) Infection courses of WT control (n = 10) and IRF3 KO (n = 12) mice infected with 1 × 106 IFU of C. muridarum (P = 0.067, two-way ANOVA). SD, standard deviation. (B) In an independent experiment, IFU measurements from day 4 postinfection in cervical lysates from individual WT (n = 5) and IRF3 KO (n = 4) mice are represented. The line represents the mean, while each dot represents the value from an individual mouse. An asterisk denotes a statistically significant difference (P < 0.05) as measured by a two-tailed t test.