Fig. 5.
Cytokine levels in genital secretions of IRF3 KO mice. WT control (n = 5) and IRF3 KO (n = 6) mice were infected with 1 × 106 IFU/ml of C. muridarum. IFN-β (A), Cxcl10 (B), IL-1β (C), TNF-α (D), IFN-γ (E), and MCP-1 (F) protein were quantified in genital tract secretions collected from infected mice at various times postinfection. Data for all panels represent the mean cytokine concentrations ± the standard errors of the means calculated from values obtained by assaying individual mouse secretions separately. An asterisk denotes a statistically significant difference (P < 0.05) on the particular day postinfection between values for WT and IRF3 KO mice.