Table 1.
mRNA levels of innate and adaptive immunity genes in gastric tissue of Helicobacter-infected C57BL/6 mice
| Gene (description)b | mRNA levela |
||||
|---|---|---|---|---|---|
| H. pylori-infected mice | H. muridarum-infected mice | HmHp mice | H. hepaticus-infected mice | HhHp mice | |
| Cxcl5 (chemokine [C-X-C motif] ligand 5) | 147.2 | 7.7 | 139.7 | 45.7 | 595.8 |
| Ifn-γ (gamma interferon) | 56.4 | 1.6 | 2.4 | −1.2 | 33.6 |
| Socs1 (suppressor of cytokine signaling 1) | 17.0 | −2.4 | 1.3 | 1.4 | 11.6 |
| Cxcl1 (chemokine [C-X-C motif] ligand 1) | 11.3 | 2.2 | 4.1 | 1.5 | 22.0 |
| Cd3d (CD3 antigen, δ polypeptide) | 11.1 | 1.1 | 1.4 | −1.4 | 6.8 |
| Cxcl2 (chemokine [C-X-C motif] ligand 2) | 10.8 | 1.7 | 1.8 | 1.5 | 11.6 |
| Cd40lg (CD40 ligand) | 10.4 | 1.6 | 1.7 | −1.3 | 7.9 |
| Cd3γ (CD3 antigen, γ polypeptide) | 9.7 | 1.7 | 1.5 | −1.1 | 8.2 |
| Cd3e (CD3 antigen, ε polypeptide) | 9.5 | 1.2 | 1.0 | −1.5 | 6.9 |
| Cd8a (CD8 antigen, α chain) | 8.6 | −1.3 | −1.2 | −2.3 | 4.4 |
| Tnf-α (tumor necrosis factor alpha) | 8.1 | 1.2 | 1.3 | 1.2 | 10.1 |
| Il-21 (interleukin 21) | 6.8 | −2.7 | −1.0 | −2.1 | 4.4 |
| Il-12b (interleukin 12b) | 6.3 | 2.2 | 1.2 | −1.1 | 3.2 |
| Clec7a (C-type lectin domain family 7, member a) | 5.7 | 1.8 | 1.5 | −1.0 | 5.1 |
| Cd28 (CD28 antigen) | 5.7 | 2.4 | 2.2 | 1.1 | 4.9 |
| Cd2 (CD2 antigen) | 4.5 | 1.5 | 1.3 | −1.1 | 3.8 |
| Ccl20 (chemokine [C-C motif] ligand 20) | 4.4 | 1.4 | 11.3 | −1.0 | 3.6 |
| Icos (inducible T cell costimulator) | 4.3 | 1.9 | 1.3 | 1.2 | 4.2 |
| Cd4 (CD4 antigen) | 4.2 | 1.0 | −1.2 | −1.4 | 2.8 |
| Il-1β (interleukin 1β) | 3.8 | 1.2 | 1.5 | −1.4 | 3.2 |
| Il-7r (interleukin 7 receptor) | 3.7 | 1.9 | 1.0 | −1.2 | 2.7 |
| Il-12r-β2 (interleukin 12 receptor, β2) | 3.6 | 1.4 | −1.2 | 1.1 | 2.4 |
| Ccl1 (chemokine [C-C motif] ligand 1) | 3.5 | 1.6 | −1.0 | −1.7 | 3.9 |
| Tbx21 (T-box 21) | 3.0 | −2.7 | −2.4 | −1.3 | 2.2 |
| Mmp13 (matrix metallopeptidase 13) | 2.7 | 1.2 | 1.2 | 1.1 | 3.5 |
| Il-12r-β1 (interleukin 12 receptor, β1) | 2.6 | −1.7 | −1.9 | −1.3 | 1.9 |
| Icam1 (intercellular adhesion molecule 1) | 2.4 | 1.6 | −1.0 | −1.1 | 2.2 |
| Il-2 (interleukin 2) | 2.4 | 1.1 | −2.3 | −1.5 | −1.2 |
| Ccl2 (chemokine [C-C motif] ligand 2) | 2.2 | 2.6 | 1.0 | −1.0 | 1.6 |
| Il-25 (interleukin 25) | 2.2 | −1.2 | −1.0 | 1.1 | 2.8 |
| Il-23r (interleukin 23 receptor) | 2.1 | 5.0 | 3.7 | 2.1 | 2.5 |
| Csf2 (granulocyte-macrophage colony-stimulating factor 2) | 2.0 | 2.9 | 1.3 | 1.5 | 1.9 |
a
Fold change of gastric mRNA levels of the respective genes in the infected groups compared to that of sham controls.
b
Genes listed because mRNA levels increased by ≥2-fold in the stomachs of mono-H. pylori-infected C57BL/6 mice compared to those of sham control mice.