Table 2.
Gene mutations conferring RIF resistance identified by the MTBDRplus assay
| Conventional DST resultb (no. of slides) | No. (%) of slides | MTBDRplus assay |
|
|---|---|---|---|
| RIF patterna (rpoB) | Mutation or mutated codon (rpoB) | ||
| RIFr (47) | 27 (52.94) | ΔDWT8, MUT3 | S531L |
| 6 (11.76) | ΔWT8 | 530–533 | |
| 2 (3.92) | WT, MUT3 | S531L | |
| 2 (3.92) | ΔWT7, MUT2A | H526Y | |
| 1 (1.96) | WT, MUT2A | H526Y | |
| 1 (1.96) | WT, MUT2A, MUT3 | H526Y and S531L | |
| 3 (5.88) | ΔWT7 | 526–529 | |
| 2 (3.92) | ΔWT2 | 510–513 | |
| 3 (1.96) | ΔWT2, ΔWT3 | 510–517 | |
| RIFs (4) | 2 (3.92) | ΔWT2 | 510–513 |
| 1 (1.96) | ΔWT8, MUT3 | S531L | |
| 1 (1.96) | WT, MUT3 | S351L | |
a
WT, wild-type pattern; Δ, missing bands; MUT, mutation.
b
RIFr, rifampin resistant; RIFs, rifampin susceptible.