Table 1.

b12 variant pseudovirus neutralization

Variant	IC50a (μg/ml)
	JR-FL	JR-CSF	SHIVSF162P3
wt b12	0.023	0.88	0.13
S239A	0.026	0.77	0.09
S267G	0.024	0.37	0.11
K338A	0.028	0.16	0.15
I332E	0.027	0.64	0.10
SD/IE	0.029	0.46	0.05
SD/IE/AL	0.027	0.39	0.06
D270E	0.028	0.42	0.09
R292A	0.027	0.28	0.10
S298A	0.028	0.63	0.07
G236A	0.028	0.66	0.16
SD/IE/GA	0.059	0.45	0.11

^aThe antibody dilution causing 50% reduction (IC₅₀) in luciferase reporter gene expression was calculated by regression analysis (n=2).