Fig. 4.
Two regions of the input X4 SHIV gp41 env gene region have been transferred by intergenomic recombination into the genetic background of SHIVAD8. SGA and direct sequencing of gp41 env sequences present in plasma viral RNA at week 100 p.i. are shown. The gp41 sequences in the input SHIVAD8 and SHIVDH12 are presented in the top and bottom lines, respectively. The heptad repeat 2 (HR2), transmembrane (TM), and lentivirus lytic peptide (LLP) regions are annotated at the top. The origin of the gp41 sequences are indicated at the bottom.