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Coreceptor utilization by SHIVs containing recombinant env genes. The indicated viruses were spinoculated onto rhesus PBMC in the presence of CCR5 (AD101)- or CXCR4 (AMD3100)-specific inhibitors. Particle-associated reverse transcriptase activity released into the medium during a 14-day infection was measured in the presence or absence (dashed lined) of inhibitor.
